北海道支部について

Beyond the Dopamine Receptor:

Regulation and Roles of Serine/Threonine Protein Phosphatases

Professor Angus C.Nairn

Yale University School of Medicine, Dept of Psychiatry

平成２６年１０月２０日（月）　１７：００〜１８：３０

北海道大学薬学部１階　臨床薬学講義室

（札幌市北区北１２条西６丁目）

北海道大学大学院薬学研究院　日本薬学会北海道支部

日本生化学会北海道支部

北海道分子生物学研究会

Dopamine plays an important role in the central nervous system,

helping to control critical aspects of motor control, as well as

of reward learning. Moreover, the disruption of normal dopaminergic

neurotransmission is known to underlie neurological diseases,

including schizophrenia, Huntington's and Parkinson's disease.

Modulation of dopamine-regulated signaling pathways is also likely

to play an important role in the addictive actions of various drugs

of abuse. Our studies focus on the molecular actions of dopamine in

the medium spiny neurons of the striatum. Striatally-enriched

phosphoproteins, particularly DARPP-32, RCS (Regulator of calmodulin

signaling) and ARPP-16, have been found to mediate a variety of

actions of dopamine. Notably, each of these proteins either directly

or indirectly acts to control the activity of three major sub-classes

of serine/threonine protein phosphatases, PP1, PP2B and PP2A,

respectively. Recent studies highlighting novel aspects of the

functions of these dopamine-regulated pathways will be discussed,

with a focus on the regulation of cell signaling in specific

populations of striatal neurons.

北海道大学大学院薬学研究院 神経科学研究室

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